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Transthyretin Aggregation Pathway toward the Formation of Distinct Cytotoxic Oligomers

In order to detect small oligomeric species that may form at an early stage of aggregation, we incubated wild-type (WT) TTR under the...

A streamlined pathway to value-added molecules — ScienceDaily

For decades, chemists have aspired to do carefully controlled chemistry on carbon-hydrogen bonds. The challenge is staggering. It requires the power of a...

FDA finalizes breakthrough device guidance, plugs new safety innovation pathway

The FDA has finalized its guidance on the agency’s breakthrough device designation—and has pitched a new pathway to reward devices that innovate on...

mRNP architecture in translating and stress conditions reveals an ordered pathway...

AbstractStress granules (SGs) are transient membraneless organelles of nontranslating mRNA–protein complexes (mRNPs) that form during stress. In this study, we used multiple single-molecule...

‘Druggable’ cancer target found in pathway regulating organ size – BIOENGINEER.ORG

Credit: Wei-Chien Yuan/Boston Children's Hospital It's known that cancer involves unchecked cell growth and that a biological pathway that regulates organ size, known...

Crystallographic and spectroscopic assignment of the proton transfer pathway in [FeFe]-hydrogenases

H2 release assays and pH-dependent enzyme activitiesFor both CpI and HydA1, 11 SDM variants were generated to target residues along the putative PT...

Light shines on new pathway for quantum technology – BIOENGINEER.ORG

Credit: Sebastian Zentilomo/University of Sydney Scientists in Australia have for the first time demonstrated the protection of correlated states between paired photons –...

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